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Generic Tadalafil (10mg) 4 Tablets

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ProductSourceProduct/Source
Healthylife generic Tadalafil (10mg)BARCELONAL PHARMACIES, 2018.Healthylife
Healthylife brand Cialis (10mg)
Healthylife tablet Tadalafil (10mg)
Healthylife brand Cialis (10mg) (oral tablet)
Healthylife generic Tadalafil (10mg) (oral tablet)
Healthylife tablet Tadalafil (10mg) (oral tablet)

2024 – Cialis (Tadalafil) – the First Lawful Period – In The Public Interest!

As we look at the history of the drug Cialis and its development, we find that it is not only a PDE5 inhibitor. It has been used for over a century, but its long duration of action is still not well understood.

Cialis was originally developed by Pfizer as a treatment for pulmonary arterial hypertension (PAH). It is also approved by the US Food and Drug Administration (FDA) for erectile dysfunction.

Cialis has since been a significant player in the field of men and has become the leading ED medication of its kind.

While the medication was originally developed by Pfizer, it has also become one of the most popular treatments for sexual dysfunction, with a long-standing history in the field of medicine.

The History of Cialis

The first treatment for erectile dysfunction was Cialis. In the 1960s, Pfizer developed the first drug that was approved by the FDA for this purpose. As a result, Cialis became the most prescribed drug of all the major erectile dysfunction drugs. However, in the 1980s, the US Food and Drug Administration (FDA) approved a different medication called Tadalafil, which was designed to treat both ED and PAH.

The drug was first developed by Eli Lilly, and then by Pfizer, which had discovered the ability to increase blood flow to the penis, thereby facilitating erections.

Cialis was launched in the UK in 1988, and in Australia in 1993.

The market for Cialis was already big in the late 1990s, with many patients reporting prolonged erections. By the time Cialis became available in the UK, the demand for the medication had soared, and the treatment period had extended to around 40 years.

In 1996, Pfizer acquired the rights to sell the drug in the USA and UK. However, the patent on the drug expired in 2010, allowing Eli Lilly and Company to sell the original medication in the US and UK. However, the FDA later gave the brand name to Tadalafil.

Development of Cialis – A Brief History

The development of Cialis was one of the first drugs to be introduced in the world. As early as the 1950s, Pfizer was developing a PDE5 inhibitor called Tadalafil, which was specifically designed to treat erectile dysfunction. It was later discovered that Tadalafil could increase the blood flow to the penis, resulting in stronger and longer-lasting erections.

By the early 1960s, Pfizer had developed another ED drug called Cialis, which was also being studied for its ability to increase blood flow to the penis. It was the first drug specifically approved by the FDA for treating ED.

By 1988, the drug had become the leading treatment for erectile dysfunction, and it was also the second-most prescribed drug of all the major erectile dysfunction drugs.

However, its patent expired in 2010, allowing Eli Lilly and Company to sell the brand name Cialis in the USA and UK.

In 2021, Eli Lilly and Company became the first company to market the brand name drug, which was also the first drug to be approved by the FDA for erectile dysfunction.

Cialis in Canada

In 2019, the brand name drug became available in Canada, and the drug was approved by the Canadian Ministry of Health in October 2019.

The Canadian version of the drug was approved by the FDA, and also in the US. It was the first drug approved for erectile dysfunction.

In the US, Cialis was also being marketed by the same company that developed Viagra. Viagra was approved for use in the US in November 2019, and Cialis for use in Canada in December 2019.

Dosage and Administration of Cialis in Canada

As we have already seen, Cialis can be taken daily, even when taking it with a fatty meal.

How to Use: Using Cialis 1mg Tablets as directed on the label is easy. Take the medication in the dose and duration as advised by your doctor. Swallow the tablet whole with a glass of water. Do not crush or chew the tablets. Use the medication regularly. To see the most up to date information on Cialis, visit this site: https://www.drugs.com/citazos/citazos.html

Possible Side Effects:Common side effects may include headache, facial flushing, indigestion, nasal congestion, dizziness, or back pain. If any of these side effects persist or worsen, contact your doctor immediately. More information about Cialis can be found on the manufacturer's website. Consult your doctor or pharmacist for more details. Cialis is used to treat erectile dysfunction (ED) in men. This medication works by increasing blood flow to the penis. This helps men who have difficulties getting or keeping an erection to have sex. It is important to get back to a normal sexual life when taking Cialis. Cialis is taken orally once a day with or without food. Do not crush or chew the tablet. Tell your doctor or pharmacist if you are taking any other medications, including any medication or supplements you are taking.

Drug Interactions:Cialis can interact with other medications you are taking:Food:Other medications may interact with Cialis. Tell your doctor or pharmacist about all the medications you are taking, even those that do not appear on this list. This may include prescription or over-the-counter medications, vitamins, or herbal supplements. Be sure to tell your doctor and pharmacist about all the products you are taking, even those products that do not appear on this list.

Precautions:This medication does not cure erectile dysfunction (ED). Sexual stimulation is still required for the medication to work. Make sure you tell your doctor about all the products you are taking, even those that are not listed on the medication package. Make sure you tell your doctor about all the products you are taking, even products that are not on this drug list.

Side Effects:Cialis may cause side effects. Tell your doctor if any of these most common side effects:Mild to moderate headache,Mild to moderate nausea,Nausea, vomiting, or diarrhea. Less common side effects that may also include back pain (back pain is a symptom of diabetes, muscle aches), muscle aches, or back pain (back pain is a symptom of heart problems, high blood pressure, or high cholesterol) may not be all that serious. Your doctor may need to change the dose or type of medication you are taking. Tell your doctor if you are pregnant or plan to become pregnant. Cialis may cause side effects in newborns. Tell your doctor if you are breast-feeding or planning to breast-feed. Cialis may cause side effects in infants. Tell your doctor if you are taking any other medications, including any supplements or herbal products. Some drugs may interfere with Cialis. Your doctor should check your progress, including blood pressure, cholesterol, and blood sugar, before you start, stop or change the dose of any medication you are taking.

Tell your doctor or pharmacist about all the medications you are taking, including prescription and non-prescription medications, vitamins, and herbal supplements. Be sure you tell your doctor and pharmacist about all the products you are taking, even medications that are not on this drug list.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
RicanMix (2009-10-26)

Key Drug-Food Interactions:

Here are the key drug-food interactions:

C.

Here are the key drug-food Interactions:

  • Grapefruit and Grape Juice: Composed of taster fruits and grapefruit juice can promote the production of tadalafil by a different enzyme, which may enhance its blood-pressure-lowering effects.
  • : Though not a direct interaction, combining Cialis with certain alcohol consumption might worsen side effects like headaches or increase heart rate in sensitive individuals.

Cialis and Viagra: What's the Difference?

Cialis and Viagra are both prescribed to treat erectile dysfunction (ED) in men, but the differences in the effects are often subtle and subtle. Viagra is a phosphodiesterase-5 (PDE-5) inhibitor, while Cialis is a phosphodiesterase-6 (PDE-6) inhibitor. While both medications can help men with ED, there are some key differences between the two.

Cialis and Viagra both increase blood flow to the penis, allowing a more extended and longer-lasting erection. Viagra's effects last for about a month's time, and it can last up to 36 hours after consumption.

The difference in duration of action can be attributed to its effects on the PDE-5 enzymes that help relax blood vessels and improve blood flow. Both medications help men with ED get and maintain an erection when sexually aroused. However, Viagra is more likely to have a prolonged effect, and Cialis and Viagra can last longer in men with ED.

The main difference between Cialis and Viagra is in how they work. Cialis works by relaxing blood vessels in the penis, allowing more blood to flow into it, which can help men achieve and maintain erections. On the other hand, Viagra's effects last for up to 36 hours, whereas Cialis lasts for about 8 hours.